Symbol: Name: ID: |
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) GFS:6791 |
Gene name: | CDKN2C |
Chromosome: | 1p32.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | INK4C, p18 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:105388 | Rat Genome Database ID: | RGD:2325 |
HGNC ID: | HGNC:1789 | RefSeq IDs: | NM_001262 |
Entrez Gene ID: | 1031 | Ensembl Gene ID: | ENSG00000123080 |
VEGA IDs: | OTTHUMG00000008046 | UniProt ID: | P42773 |
UCSC ID: | uc001csg.2 | OMIM ID: | 603369 |
Pubmed: | PMID8001816 PMID 9636670 | ||
CCDS IDs: | CCDSCCDS555.1 |
Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene.
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008].
Function: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
Products for CDKN2C gene
Catalog | Product Name | Application | Company |
GFS:E06791 | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); ELISA kit | ELISA | n/a |
GFS:A06791 | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); Anti | ANTIBODIES | n/a |
GFS:P06791 | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); Protien | Protien | n/a |