Symbol: Name: ID: |
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 GFS:4669 |
Gene name: | CACNA2D3 |
Chromosome: | 3p21.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | HSA272268 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1338890 | Rat Genome Database ID: | RGD:631361 |
HGNC ID: | HGNC:15460 | RefSeq IDs: | NM_018398 |
Entrez Gene ID: | 55799 | Ensembl Gene ID: | ENSG00000157445 |
VEGA IDs: | OTTHUMG00000158580 | UniProt ID: | Q8IZS8 |
UCSC ID: | uc003dhf.2 | OMIM ID: | 606399 |
Pubmed: | PMID11245980 | ||
CCDS IDs: |
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity).
Products for CACNA2D3 gene
Catalog | Product Name | Application | Company |
GFS:E04669 | calcium channel, voltage-dependent, alpha 2/delta subunit 3; ELISA kit | ELISA | n/a |
GFS:A04669 | calcium channel, voltage-dependent, alpha 2/delta subunit 3; Anti | ANTIBODIES | n/a |
GFS:P04669 | calcium channel, voltage-dependent, alpha 2/delta subunit 3; Protien | Protien | n/a |