Symbol: Name: ID: |
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit GFS:3344 |
Gene name: | CACNA1B |
Chromosome: | 9q34 |
Previous Symbols: | CACNL1A5 |
Previous Names: | |
Aliases: | Cav2.2, CACNN |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88296 | Rat Genome Database ID: | RGD:628852 |
HGNC ID: | HGNC:1389 | RefSeq IDs: | NM_000718 |
Entrez Gene ID: | 774 | Ensembl Gene ID: | ENSG00000148408 |
VEGA IDs: | OTTHUMG00000021002 | UniProt ID: | Q00975 |
UCSC ID: | uc004cog.2 | OMIM ID: | 601012 |
Pubmed: | PMID8825650 PMID 16382099 | ||
CCDS IDs: |
The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
Products for CACNA1B gene
Catalog | Product Name | Application | Company |
GFS:E03344 | calcium channel, voltage-dependent, N type, alpha 1B subunit; ELISA kit | ELISA | n/a |
GFS:A03344 | calcium channel, voltage-dependent, N type, alpha 1B subunit; Anti | ANTIBODIES | n/a |
GFS:P03344 | calcium channel, voltage-dependent, N type, alpha 1B subunit; Protien | Protien | n/a |