Symbol: Name: ID: |
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit GFS:3398 |
Gene name: | CACNA1I |
Chromosome: | 22q13.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | Cav3.3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2178051 | Rat Genome Database ID: | RGD:68944 |
HGNC ID: | HGNC:1396 | RefSeq IDs: | NM_001003406 |
Entrez Gene ID: | 8911 | Ensembl Gene ID: | ENSG00000100346 |
VEGA IDs: | OTTHUMG00000151096 | UniProt ID: | Q9P0X4 |
UCSC ID: | uc003ayd.2 | OMIM ID: | 608230 |
Pubmed: | PMID10454147 PMID 16382099 | ||
CCDS IDs: | CCDSCCDS46710.1 CCDS CCDS46711.1 |
Voltage-dependent calcium channels control the rapid entry of Ca(2+) into a variety of cell types and are therefore involved in both electrical and cellular signaling. T-type channels, such as CACNA1I, are activated by small membrane depolarizations and can generate burst firing and pacemaker activity.[supplied by OMIM, Oct 2004].
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity).
Products for CACNA1I gene
Catalog | Product Name | Application | Company |
GFS:E03398 | calcium channel, voltage-dependent, T type, alpha 1I subunit; ELISA kit | ELISA | n/a |
GFS:A03398 | calcium channel, voltage-dependent, T type, alpha 1I subunit; Anti | ANTIBODIES | n/a |
GFS:P03398 | calcium channel, voltage-dependent, T type, alpha 1I subunit; Protien | Protien | n/a |