Symbol: Name: ID: |
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 GFS:3434 |
Gene name: | CACNA2D2 |
Chromosome: | 3p21.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0558 |
Name Aliases: | gene 26 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929813 | Rat Genome Database ID: | RGD:631360 |
HGNC ID: | HGNC:1400 | RefSeq IDs: | NM_001005505 |
Entrez Gene ID: | 9254 | Ensembl Gene ID: | ENSG00000007402 |
VEGA IDs: | OTTHUMG00000156887 | UniProt ID: | Q9NY47 |
UCSC ID: | uc003dap.2 | OMIM ID: | 607082 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS33763.1 |
Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
Products for CACNA2D2 gene
Catalog | Product Name | Application | Company |
GFS:E03434 | calcium channel, voltage-dependent, alpha 2/delta subunit 2; ELISA kit | ELISA | n/a |
GFS:A03434 | calcium channel, voltage-dependent, alpha 2/delta subunit 2; Anti | ANTIBODIES | n/a |
GFS:P03434 | calcium channel, voltage-dependent, alpha 2/delta subunit 2; Protien | Protien | n/a |