Symbol: Name: ID: |
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit GFS:3363 |
Gene name: | CACNA1E |
Chromosome: | 1q25-q31 |
Previous Symbols: | CACNL1A6 |
Previous Names: | |
Aliases: | Cav2.3, BII, CACH6 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:106217 | Rat Genome Database ID: | RGD:2246 |
HGNC ID: | HGNC:1392 | RefSeq IDs: | NM_000721 |
Entrez Gene ID: | 777 | Ensembl Gene ID: | ENSG00000198216 |
VEGA IDs: | OTTHUMG00000037301 | UniProt ID: | Q15878 |
UCSC ID: | uc001gow.2 | OMIM ID: | 601013 |
Pubmed: | PMID8388125 PMID 16382099 | ||
CCDS IDs: |
Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011].
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels contaning alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
Products for CACNA1E gene
Catalog | Product Name | Application | Company |
GFS:E03363 | calcium channel, voltage-dependent, R type, alpha 1E subunit; ELISA kit | ELISA | n/a |
GFS:A03363 | calcium channel, voltage-dependent, R type, alpha 1E subunit; Anti | ANTIBODIES | n/a |
GFS:P03363 | calcium channel, voltage-dependent, R type, alpha 1E subunit; Protien | Protien | n/a |