Symbol: Name: ID: |
SP3 Sp3 transcription factor GFS:1109 |
Gene name: | SP3 |
Chromosome: | 2q31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SPR-2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1277166 | Rat Genome Database ID: | RGD:1583765 |
HGNC ID: | HGNC:11208 | RefSeq IDs: | NM_001017371 |
Entrez Gene ID: | 6670 | Ensembl Gene ID: | ENSG00000172845 |
VEGA IDs: | OTTHUMG00000132333 | UniProt ID: | Q02447 |
UCSC ID: | uc002uig.2 | OMIM ID: | 601804 |
Pubmed: | PMID1341900 PMID 1454515 | ||
CCDS IDs: | CCDSCCDS2254.1 CCDS CCDS46452.1 |
Sp3 transcription factor, also known as SP3, refers to both a protein and the gene it is encoded by. This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq].
Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.
Products for SP3 gene
Catalog | Product Name | Application | Company |
GFS:E01109 | Sp3 transcription factor; ELISA kit | ELISA | n/a |
GFS:A01109 | Sp3 transcription factor; Anti | ANTIBODIES | n/a |
GFS:P01109 | Sp3 transcription factor; Protien | Protien | n/a |