Symbol: Name: ID: |
SP1 Sp1 transcription factor GFS:1106 |
Gene name: | SP1 |
Chromosome: | 12q13.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | specificity protein 1 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98372 | Rat Genome Database ID: | RGD:3738 |
HGNC ID: | HGNC:11205 | RefSeq IDs: | NM_003109 |
Entrez Gene ID: | 6667 | Ensembl Gene ID: | ENSG00000185591 |
VEGA IDs: | UniProt ID: | P08047 | |
UCSC ID: | uc001scw.2 | OMIM ID: | 189906 |
Pubmed: | PMID1662663 | ||
CCDS IDs: | CCDSCCDS8857.1 CCDS CCDS44898.1 |
Sp1, also known as Specificity Protein 1, is a human transcription factor involved in gene expression in the early development of an organism. It belongs to the Sp/KLF family of transcription factors. The protein is 785 amino acids long, with a molecular weight of 81 kDA.The SP1 transcription factor contains a zinc finger protein motif, by which it binds directly to DNA and enhances gene transcription. Its zinc fingers are of the Cys2/His2 type and bind the consensus sequence 5'-(G/T)GGGCGG(G/A)(G/A)(C/T)-3' (GC box element). It was discovered in 1983 and has since been modified to form Sp1C, which has a zinc finger protein DNA binding domain.
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.
Products for SP1 gene
Catalog | Product Name | Application | Company |
GFS:E01106 | Sp1 transcription factor; ELISA kit | ELISA | n/a |
GFS:A01106 | Sp1 transcription factor; Anti | ANTIBODIES | n/a |
GFS:P01106 | Sp1 transcription factor; Protien | Protien | n/a |