Symbol: Name: ID: |
SPAG6 sperm associated antigen 6 GFS:1115 |
Gene name: | SPAG6 |
Chromosome: | 10p12.31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | Repro-SA-1, pf16 |
Name Aliases: | axoneme central apparatus protein |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1354388 | Rat Genome Database ID: | RGD:1310892 |
HGNC ID: | HGNC:11215 | RefSeq IDs: | NM_012443 |
Entrez Gene ID: | 9576 | Ensembl Gene ID: | ENSG00000077327 |
VEGA IDs: | OTTHUMG00000017808 | UniProt ID: | O75602 |
UCSC ID: | uc001iri.2 | OMIM ID: | 605730 |
Pubmed: | PMID10493827 | ||
CCDS IDs: | CCDSCCDS7139.1 CCDS CCDS7140.1 |
Sperm-associated antigen 6 is a protein that in humans is encoded by the SPAG6 gene. The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. [provided by RefSeq].
Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility (By similarity).
Products for SPAG6 gene
Catalog | Product Name | Application | Company |
GFS:E01115 | sperm associated antigen 6; ELISA kit | ELISA | n/a |
GFS:A01115 | sperm associated antigen 6; Anti | ANTIBODIES | n/a |
GFS:P01115 | sperm associated antigen 6; Protien | Protien | n/a |