Symbol: Name: ID: |
SPAG1 sperm associated antigen 1 GFS:1113 |
Gene name: | SPAG1 |
Chromosome: | 8q22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SP75, FLJ32920, HSD-3.8, TPIS |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1349387 | Rat Genome Database ID: | RGD:1310702 |
HGNC ID: | HGNC:11212 | RefSeq IDs: | NM_003114 |
Entrez Gene ID: | 6674 | Ensembl Gene ID: | ENSG00000104450 |
VEGA IDs: | UniProt ID: | Q07617 | |
UCSC ID: | uc003yjh.1 | OMIM ID: | 603395 |
Pubmed: | PMID16368546 | ||
CCDS IDs: | CCDSCCDS34930.1 |
Sperm-associated antigen 1 is a protein that in humans is encoded by the SPAG1 gene. The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq].
Products for SPAG1 gene
Catalog | Product Name | Application | Company |
GFS:E01113 | sperm associated antigen 1; ELISA kit | ELISA | n/a |
GFS:A01113 | sperm associated antigen 1; Anti | ANTIBODIES | n/a |
GFS:P01113 | sperm associated antigen 1; Protien | Protien | n/a |