Symbol: Name: ID: |
SPARC secreted protein, acidic, cysteine-rich (osteonectin) GFS:1119 |
Gene name: | SPARC |
Chromosome: | 5q31-q33 |
Previous Symbols: | ON |
Previous Names: | |
Aliases: | |
Name Aliases: | cysteine-rich protein, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98373 | Rat Genome Database ID: | RGD:3742 |
HGNC ID: | HGNC:11219 | RefSeq IDs: | NM_003118 |
Entrez Gene ID: | 6678 | Ensembl Gene ID: | ENSG00000113140 |
VEGA IDs: | OTTHUMG00000130122 | UniProt ID: | P09486 |
UCSC ID: | uc003lui.2 | OMIM ID: | 182120 |
Pubmed: | PMID2838412 PMID 3410046 | ||
CCDS IDs: | CCDSCCDS4318.1 |
Osteonectin is a glycoprotein in the bone that binds sodium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone mineral calcium. Some current research shows a correlation between osteonectin over expression and ampullary cancers and chronic pancreatitis.
Secreted protein acidic and rich in cysteine/osteonectin/BM40, or SPARC, is a matrix-associated protein that elicits changes in cell shape, inhibits cell-cycle progression, and influences the synthesis of extracellular matrix (ECM) (Bradshaw et al., 2003 [PubMed 12721366]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Products for SPARC gene
Catalog | Product Name | Application | Company |
GFS:E01119 | secreted protein, acidic, cysteine-rich (osteonectin); ELISA kit | ELISA | n/a |
GFS:A01119 | secreted protein, acidic, cysteine-rich (osteonectin); Anti | ANTIBODIES | n/a |
GFS:P01119 | secreted protein, acidic, cysteine-rich (osteonectin); Protien | Protien | n/a |