Symbol: Name: ID: |
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) GFS:1117 |
Gene name: | SPAM1 |
Chromosome: | 7q31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | HYAL5, PH-20, SPAG15 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109335 | Rat Genome Database ID: | RGD:620547 |
HGNC ID: | HGNC:11217 | RefSeq IDs: | NM_001174044 |
Entrez Gene ID: | 6677 | Ensembl Gene ID: | ENSG00000106304 |
VEGA IDs: | OTTHUMG00000157284 | UniProt ID: | P38567 |
UCSC ID: | uc003vle.2 | OMIM ID: | 600930 |
Pubmed: | PMID8282124 PMID 8575780 | ||
CCDS IDs: | CCDSCCDS5790.1 CCDS CCDS5791.1 |
Hyaluronidase PH-20 is an enzyme that in humans is encoded by the SPAM1 gene. Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq) .
Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.
Products for SPAM1 gene
Catalog | Product Name | Application | Company |
GFS:E01117 | sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); ELISA kit | ELISA | n/a |
GFS:A01117 | sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); Anti | ANTIBODIES | n/a |
GFS:P01117 | sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); Protien | Protien | n/a |