Symbol: Name: ID: |
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced GFS:1258 |
Gene name: | STAT6 |
Chromosome: | 12q13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | D12S1644, IL-4-STAT |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103034 | Rat Genome Database ID: | RGD:1309063 |
HGNC ID: | HGNC:11368 | RefSeq IDs: | NM_001178078 |
Entrez Gene ID: | 6778 | Ensembl Gene ID: | ENSG00000166888 |
VEGA IDs: | UniProt ID: | P42226 | |
UCSC ID: | uc001sna.2 | OMIM ID: | 601512 |
Pubmed: | PMID9605853 PMID 8085155 | ||
CCDS IDs: | CCDSCCDS8931.1 |
STAT6 is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
Function: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
Products for STAT6 gene
Catalog | Product Name | Application | Company |
GFS:E01258 | signal transducer and activator of transcription 6, interleukin-4 induced; ELISA kit | ELISA | n/a |
GFS:A01258 | signal transducer and activator of transcription 6, interleukin-4 induced; Anti | ANTIBODIES | n/a |
GFS:P01258 | signal transducer and activator of transcription 6, interleukin-4 induced; Protien | Protien | n/a |