Symbol: Name: ID: |
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) GFS:1254 |
Gene name: | STAT3 |
Chromosome: | 17q21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | APRF |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103038 | Rat Genome Database ID: | RGD:3772 |
HGNC ID: | HGNC:11364 | RefSeq IDs: | NM_003150 |
Entrez Gene ID: | 6774 | Ensembl Gene ID: | ENSG00000168610 |
VEGA IDs: | OTTHUMG00000150645 | UniProt ID: | P40763 |
UCSC ID: | uc002hzl.1 | OMIM ID: | 102582 |
Pubmed: | PMID7512451 | ||
CCDS IDs: | CCDSCCDS32656.1 CCDS CCDS32657.1 |
Signal transducer and activator of transcription 3 also known as STAT3 is a transcription factor which in humans is encoded by the STAT3 gene. The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq].
Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.
Products for STAT3 gene
Catalog | Product Name | Application | Company |
GFS:E01254 | signal transducer and activator of transcription 3 (acute-phase response factor); ELISA kit | ELISA | n/a |
GFS:A01254 | signal transducer and activator of transcription 3 (acute-phase response factor); Anti | ANTIBODIES | n/a |
GFS:P01254 | signal transducer and activator of transcription 3 (acute-phase response factor); Protien | Protien | n/a |