Symbol: Name: ID: |
STAT2 signal transducer and activator of transcription 2, 113kDa GFS:1253 |
Gene name: | STAT2 |
Chromosome: | 12q13.2 |
Previous Symbols: | |
Previous Names: | signal transducer and activator of transcription 2, 113kD |
Aliases: | STAT113 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103039 | Rat Genome Database ID: | RGD:1311649 |
HGNC ID: | HGNC:11363 | RefSeq IDs: | NM_005419 |
Entrez Gene ID: | 6773 | Ensembl Gene ID: | ENSG00000170581 |
VEGA IDs: | UniProt ID: | P52630 | |
UCSC ID: | uc001slc.2 | OMIM ID: | 600556 |
Pubmed: | PMID7885841 | ||
CCDS IDs: | CCDSCCDS8917.1 |
Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Products for STAT2 gene
Catalog | Product Name | Application | Company |
GFS:E01253 | signal transducer and activator of transcription 2, 113kDa; ELISA kit | ELISA | n/a |
GFS:A01253 | signal transducer and activator of transcription 2, 113kDa; Anti | ANTIBODIES | n/a |
GFS:P01253 | signal transducer and activator of transcription 2, 113kDa; Protien | Protien | n/a |