Symbol: Name: ID: |
STAT5B signal transducer and activator of transcription 5B GFS:1257 |
Gene name: | STAT5B |
Chromosome: | 17q11.2 |
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Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103035 | Rat Genome Database ID: | RGD:3774 |
HGNC ID: | HGNC:11367 | RefSeq IDs: | NM_012448 |
Entrez Gene ID: | 6777 | Ensembl Gene ID: | ENSG00000173757 |
VEGA IDs: | OTTHUMG00000150724 | UniProt ID: | P51692 |
UCSC ID: | uc002hzh.2 | OMIM ID: | 604260 |
Pubmed: | PMID8631883 | ||
CCDS IDs: | CCDSCCDS11423.1 |
Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene. STAT5B orthologs have been identified in most placentals for which complete genome data are available. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
Products for STAT5B gene
Catalog | Product Name | Application | Company |
GFS:E01257 | signal transducer and activator of transcription 5B; ELISA kit | ELISA | n/a |
GFS:A01257 | signal transducer and activator of transcription 5B; Anti | ANTIBODIES | n/a |
GFS:P01257 | signal transducer and activator of transcription 5B; Protien | Protien | n/a |