Symbol: Name: ID: |
RDH8 retinol dehydrogenase 8 (all-trans) GFS:3761 |
Gene name: | RDH8 |
Chromosome: | 19p13.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | PRRDH, SDR28C2 |
Name Aliases: | short chain dehydrogenase/reductase family 28C, member 2 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2685028 | Rat Genome Database ID: | RGD:1589829 |
HGNC ID: | HGNC:14423 | RefSeq IDs: | NM_015725 |
Entrez Gene ID: | 50700 | Ensembl Gene ID: | ENSG00000080511 |
VEGA IDs: | UniProt ID: | Q9NYR8 | |
UCSC ID: | uc002mmr.2 | OMIM ID: | 608575 |
Pubmed: | PMID10753906 PMID 19027726 | ||
CCDS IDs: | CCDSCCDS12223.1 |
Retinol dehydrogenase 8 is an enzyme that in humans is encoded by the RDH8 gene.
All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 [PubMed 10753906]). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001 [PubMed 11710234]). This is a rate-limiting step in the visual cycle (Saari et al., 1998 [PubMed 9667000]).[supplied by OMIM, Mar 2008].
Function: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity).
Products for RDH8 gene
Catalog | Product Name | Application | Company |
GFS:E03761 | retinol dehydrogenase 8 (all-trans); ELISA kit | ELISA | n/a |
GFS:A03761 | retinol dehydrogenase 8 (all-trans); Anti | ANTIBODIES | n/a |
GFS:P03761 | retinol dehydrogenase 8 (all-trans); Protien | Protien | n/a |