| Symbol: Name: ID: |
PPP4R2 protein phosphatase 4, regulatory subunit 2 GFS:7169 |
| Gene name: | PPP4R2 |
| Chromosome: | 3q29 |
| Previous Symbols: | |
| Previous Names: | |
| Aliases: | |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:3027896 | Rat Genome Database ID: | RGD:1307312 |
| HGNC ID: | HGNC:18296 | RefSeq IDs: | NM_174907 |
| Entrez Gene ID: | 151987 | Ensembl Gene ID: | ENSG00000163605 |
| VEGA IDs: | OTTHUMG00000158816 | UniProt ID: | Q9NY27 |
| UCSC ID: | uc003dph.1 | OMIM ID: | |
| Pubmed: | PMID10769191 | ||
| CCDS IDs: | CCDSCCDS2917.1 | ||
Function: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
Products for PPP4R2 gene
| Catalog | Product Name | Application | Company |
| GFS:E07169 | protein phosphatase 4, regulatory subunit 2; ELISA kit | ELISA | n/a |
| GFS:A07169 | protein phosphatase 4, regulatory subunit 2; Anti | ANTIBODIES | n/a |
| GFS:P07169 | protein phosphatase 4, regulatory subunit 2; Protien | Protien | n/a |
