Symbol: Name: ID: |
PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A GFS:3721 |
Gene name: | PPP1R15A |
Chromosome: | 19q13.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | GADD34 |
Name Aliases: | growth arrest and DNA-damage-inducible 34 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927072 | Rat Genome Database ID: | RGD:621526 |
HGNC ID: | HGNC:14375 | RefSeq IDs: | NM_014330 |
Entrez Gene ID: | 23645 | Ensembl Gene ID: | ENSG00000087074 |
VEGA IDs: | UniProt ID: | O75807 | |
UCSC ID: | uc002pky.3 | OMIM ID: | 611048 |
Pubmed: | PMID9153226 PMID 9413226 | ||
CCDS IDs: | CCDSCCDS12738.1 |
Protein phosphatase 1 regulatory subunit 15A is an enzyme that in humans is encoded by the PPP1R15A gene.
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.
Products for PPP1R15A gene
Catalog | Product Name | Application | Company |
GFS:E03721 | protein phosphatase 1, regulatory (inhibitor) subunit 15A; ELISA kit | ELISA | n/a |
GFS:A03721 | protein phosphatase 1, regulatory (inhibitor) subunit 15A; Anti | ANTIBODIES | n/a |
GFS:P03721 | protein phosphatase 1, regulatory (inhibitor) subunit 15A; Protien | Protien | n/a |