Symbol: Name: ID: |
PPP1R3B protein phosphatase 1, regulatory (inhibitor) subunit 3B GFS:4226 |
Gene name: | PPP1R3B |
Chromosome: | 8p23.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | GL, FLJ14005, PPP1R4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2177268 | Rat Genome Database ID: | RGD:621600 |
HGNC ID: | HGNC:14942 | RefSeq IDs: | NM_001201329 |
Entrez Gene ID: | 79660 | Ensembl Gene ID: | ENSG00000173281 |
VEGA IDs: | OTTHUMG00000129329 | UniProt ID: | Q86XI6 |
UCSC ID: | uc003wsn.3 | OMIM ID: | 610541 |
Pubmed: | PMID11948623 PMID 17555403 | ||
CCDS IDs: | CCDSCCDS5973.1 |
This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011].
Function: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity).
Products for PPP1R3B gene
Catalog | Product Name | Application | Company |
GFS:E04226 | protein phosphatase 1, regulatory (inhibitor) subunit 3B; ELISA kit | ELISA | n/a |
GFS:A04226 | protein phosphatase 1, regulatory (inhibitor) subunit 3B; Anti | ANTIBODIES | n/a |
GFS:P04226 | protein phosphatase 1, regulatory (inhibitor) subunit 3B; Protien | Protien | n/a |