Symbol: Name: ID: |
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A GFS:4159 |
Gene name: | PPP1R14A |
Chromosome: | 19q13.1 |
Previous Symbols: | PPP1INL |
Previous Names: | |
Aliases: | CPI-17 |
Name Aliases: | 17-kDa PKC-potentiated inhibitory protein of PP1, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1931139 | Rat Genome Database ID: | RGD:620536 |
HGNC ID: | HGNC:14871 | RefSeq IDs: | NM_033256 |
Entrez Gene ID: | 94274 | Ensembl Gene ID: | ENSG00000167641 |
VEGA IDs: | UniProt ID: | Q96A00 | |
UCSC ID: | uc002ohq.2 | OMIM ID: | 608153 |
Pubmed: | PMID11467857 | ||
CCDS IDs: | CCDSCCDS12509.1 |
Protein phosphatase 1 regulatory subunit 14A also known as CPI-17 (C-kinase potentiated Protein phosphatase-1 Inhibitor Mr = 17 kDa) is a protein that in humans is encoded by the PPP1R14A gene.
The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011].
Function: Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Products for PPP1R14A gene
Catalog | Product Name | Application | Company |
GFS:E04159 | protein phosphatase 1, regulatory (inhibitor) subunit 14A; ELISA kit | ELISA | n/a |
GFS:A04159 | protein phosphatase 1, regulatory (inhibitor) subunit 14A; Anti | ANTIBODIES | n/a |
GFS:P04159 | protein phosphatase 1, regulatory (inhibitor) subunit 14A; Protien | Protien | n/a |