Symbol: Name: ID: |
PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B GFS:4233 |
Gene name: | PPP1R13B |
Chromosome: | 14q32.33 |
Previous Symbols: | |
Previous Names: | |
Aliases: | p53BP2-like, KIAA0771, p85, ASPP1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1336199 | Rat Genome Database ID: | RGD:1304651 |
HGNC ID: | HGNC:14950 | RefSeq IDs: | NM_015316 |
Entrez Gene ID: | 23368 | Ensembl Gene ID: | ENSG00000088808 |
VEGA IDs: | UniProt ID: | Q96KQ4 | |
UCSC ID: | uc001yof.1 | OMIM ID: | 606455 |
Pubmed: | PMID9872452 | ||
CCDS IDs: | CCDSCCDS41997.1 |
Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.
Products for PPP1R13B gene
Catalog | Product Name | Application | Company |
GFS:E04233 | protein phosphatase 1, regulatory (inhibitor) subunit 13B; ELISA kit | ELISA | n/a |
GFS:A04233 | protein phosphatase 1, regulatory (inhibitor) subunit 13B; Anti | ANTIBODIES | n/a |
GFS:P04233 | protein phosphatase 1, regulatory (inhibitor) subunit 13B; Protien | Protien | n/a |