Symbol: Name: ID: |
PPP1R16B protein phosphatase 1, regulatory (inhibitor) subunit 16B GFS:4987 |
Gene name: | PPP1R16B |
Chromosome: | 20q11.23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0823, TIMAP, ANKRD4 |
Name Aliases: | TGF-beta-inhibited membrane-associated protein, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2151841 | Rat Genome Database ID: | RGD:1589460 |
HGNC ID: | HGNC:15850 | RefSeq IDs: | NM_001172735 |
Entrez Gene ID: | 26051 | Ensembl Gene ID: | ENSG00000101445 |
VEGA IDs: | OTTHUMG00000032465 | UniProt ID: | Q96T49 |
UCSC ID: | uc002xje.2 | OMIM ID: | 613275 |
Pubmed: | PMID10048485 PMID 12055102 | ||
CCDS IDs: | CCDSCCDS13309.1 |
The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010].
Function: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.
Products for PPP1R16B gene
Catalog | Product Name | Application | Company |
GFS:E04987 | protein phosphatase 1, regulatory (inhibitor) subunit 16B; ELISA kit | ELISA | n/a |
GFS:A04987 | protein phosphatase 1, regulatory (inhibitor) subunit 16B; Anti | ANTIBODIES | n/a |
GFS:P04987 | protein phosphatase 1, regulatory (inhibitor) subunit 16B; Protien | Protien | n/a |