Symbol: Name: ID: |
PI4K2B phosphatidylinositol 4-kinase type 2 beta GFS:7093 |
Gene name: | PI4K2B |
Chromosome: | 4p15.31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | PI4KIIB, FLJ11105, PIK42B |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914323 | Rat Genome Database ID: | RGD:1359515 |
HGNC ID: | HGNC:18215 | RefSeq IDs: | NM_018323 |
Entrez Gene ID: | 55300 | Ensembl Gene ID: | ENSG00000038210 |
VEGA IDs: | OTTHUMG00000128564 | UniProt ID: | Q8TCG2 |
UCSC ID: | uc003grk.2 | OMIM ID: | 612101 |
Pubmed: | PMID11923287 | ||
CCDS IDs: | CCDSCCDS3433.1 |
Phosphatidylinositol 4-kinase type 2-beta is an enzyme that in humans is encoded by the PI4K2B gene.
Phosphatidylinositol 4-kinases (PI4Ks) phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate (PIP), an immediate precursor of several important signaling and scaffolding molecules. PIP itself may also have direct functional and structural roles. PI4K2B is a primarily cytosolic PI4K that is recruited to membranes, where it stimulates phosphatidylinositol 4,5-bisphosphate synthesis (Wei et al., 2002 [PubMed 12324459]).[supplied by OMIM, Jun 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Function: Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
Products for PI4K2B gene
Catalog | Product Name | Application | Company |
GFS:E07093 | phosphatidylinositol 4-kinase type 2 beta; ELISA kit | ELISA | n/a |
GFS:A07093 | phosphatidylinositol 4-kinase type 2 beta; Anti | ANTIBODIES | n/a |
GFS:P07093 | phosphatidylinositol 4-kinase type 2 beta; Protien | Protien | n/a |