Symbol: Name: ID: |
LPIN1 lipin 1 GFS:2961 |
Gene name: | LPIN1 |
Chromosome: | 2p25.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0188 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1891340 | Rat Genome Database ID: | RGD:1307646 |
HGNC ID: | HGNC:13345 | RefSeq IDs: | NM_145693 |
Entrez Gene ID: | 23175 | Ensembl Gene ID: | ENSG00000134324 |
VEGA IDs: | OTTHUMG00000119082 | UniProt ID: | Q14693 |
UCSC ID: | uc002rbt.2 | OMIM ID: | 605518 |
Pubmed: | PMID11138012 PMID 8724849 PMID 16950137 | ||
CCDS IDs: | CCDSCCDS1682.1 |
Lipin-1 is a protein that in humans is encoded by the LPIN1 gene.
This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mouse studies suggest that this gene functions during normal adipose tissue development and may also play a role in human triglyceride metabolism. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity).
Products for LPIN1 gene
Catalog | Product Name | Application | Company |
GFS:E02961 | lipin 1; ELISA kit | ELISA | n/a |
GFS:A02961 | lipin 1; Anti | ANTIBODIES | n/a |
GFS:P02961 | lipin 1; Protien | Protien | n/a |