Symbol: Name: ID: |
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 GFS:2095 |
Gene name: | SERPING1 |
Chromosome: | 11q12-q13.1 |
Previous Symbols: | C1NH |
Previous Names: | serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) |
Aliases: | C1IN, C1-INH, HAE1, HAE2 |
Name Aliases: | plasma protease C1 inhibitor, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:894696 | Rat Genome Database ID: | RGD:735225 |
HGNC ID: | HGNC:1228 | RefSeq IDs: | NM_000062 |
Entrez Gene ID: | 710 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000150304 | UniProt ID: | P05155 |
UCSC ID: | uc001nkr.1 | OMIM ID: | 606860 |
Pubmed: | PMID2026152 | ||
CCDS IDs: | CCDSCCDS7962.1 |
C1-inhibitor (C1-inh, C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement system to prevent spontaneous activation. This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq].
Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
Products for SERPING1 gene
Catalog | Product Name | Application | Company |
GFS:E02095 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; ELISA kit | ELISA | n/a |
GFS:A02095 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Anti | ANTIBODIES | n/a |
GFS:P02095 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Protien | Protien | n/a |