Symbol: Name: ID: |
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) GFS:1578 |
Gene name: | TFPI |
Chromosome: | 2q32 |
Previous Symbols: | LACI |
Previous Names: | |
Aliases: | EPI, TFI, TFPI1 |
Name Aliases: | extrinsic pathway inhibitor |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1095418 | Rat Genome Database ID: | RGD:61914 |
HGNC ID: | HGNC:11760 | RefSeq IDs: | NM_001032281 |
Entrez Gene ID: | 7035 | Ensembl Gene ID: | ENSG00000003436 |
VEGA IDs: | OTTHUMG00000132634 | UniProt ID: | P10646 |
UCSC ID: | uc002upy.2 | OMIM ID: | 152310 |
Pubmed: | PMID1993173 | ||
CCDS IDs: | CCDSCCDS2294.1 CCDS CCDS33349.1 |
Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM. This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq].
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Products for TFPI gene
Catalog | Product Name | Application | Company |
GFS:E01578 | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor); ELISA kit | ELISA | n/a |
GFS:A01578 | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor); Anti | ANTIBODIES | n/a |
GFS:P01578 | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor); Protien | Protien | n/a |