Symbol: Name: ID: |
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 GFS:1132 |
Gene name: | SPI1 |
Chromosome: | 11p12-p11.22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | PU.1, SPI-A, OF, SFPI1, SPI-1 |
Name Aliases: | SPI-1 proto-oncogene, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98282 | Rat Genome Database ID: | RGD:1359607 |
HGNC ID: | HGNC:11241 | RefSeq IDs: | NM_001080547 |
Entrez Gene ID: | 6688 | Ensembl Gene ID: | ENSG00000066336 |
VEGA IDs: | OTTHUMG00000150150 | UniProt ID: | P17947 |
UCSC ID: | uc001nfb.1 | OMIM ID: | 165170 |
Pubmed: | PMID1693183 | ||
CCDS IDs: | CCDSCCDS7933.2 CCDS CCDS44591.1 |
Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene. This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity).
Products for SPI1 gene
Catalog | Product Name | Application | Company |
GFS:E01132 | spleen focus forming virus (SFFV) proviral integration oncogene spi1; ELISA kit | ELISA | n/a |
GFS:A01132 | spleen focus forming virus (SFFV) proviral integration oncogene spi1; Anti | ANTIBODIES | n/a |
GFS:P01132 | spleen focus forming virus (SFFV) proviral integration oncogene spi1; Protien | Protien | n/a |