Symbol: Name: ID: |
HM13 histocompatibility (minor) 13 GFS:5545 |
Gene name: | HM13 |
Chromosome: | 20q11.21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | H13, dJ324O17.1, SPP, PSL3, IMP1, IMPAS, PSENL3 |
Name Aliases: | signal peptide peptidase beta, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:95886 | Rat Genome Database ID: | RGD:1308946 |
HGNC ID: | HGNC:16435 | RefSeq IDs: | NM_030789 |
Entrez Gene ID: | 81502 | Ensembl Gene ID: | ENSG00000101294 |
VEGA IDs: | OTTHUMG00000032175 | UniProt ID: | Q8TCT9 |
UCSC ID: | uc002wwc.2 | OMIM ID: | 607106 |
Pubmed: | PMID12077416 PMID 14704149 | ||
CCDS IDs: | CCDSCCDS13182.1 CCDS CCDS13183.1 CCDS CCDS42861.1 |
Minor histocompatibility antigen H13 is a protein that in humans is encoded by the HM13 gene.
The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection (By similarity). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1.
Products for HM13 gene
Catalog | Product Name | Application | Company |
GFS:E05545 | histocompatibility (minor) 13; ELISA kit | ELISA | n/a |
GFS:A05545 | histocompatibility (minor) 13; Anti | ANTIBODIES | n/a |
GFS:P05545 | histocompatibility (minor) 13; Protien | Protien | n/a |