Symbol: Name: ID: |
HMGN3 high mobility group nucleosomal binding domain 3 GFS:2128 |
Gene name: | HMGN3 |
Chromosome: | 6q14.3 |
Previous Symbols: | TRIP7 |
Previous Names: | thyroid hormone receptor interactor 7 |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2138069 | Rat Genome Database ID: | RGD:1359106 |
HGNC ID: | HGNC:12312 | RefSeq IDs: | NM_001201362 |
Entrez Gene ID: | 9324 | Ensembl Gene ID: | ENSG00000118418 |
VEGA IDs: | OTTHUMG00000015073 | UniProt ID: | Q15651 |
UCSC ID: | uc003pit.2 | OMIM ID: | 604502 |
Pubmed: | PMID7776974 PMID 11356838 | ||
CCDS IDs: | CCDSCCDS4988.1 CCDS CCDS4989.1 |
High mobility group nucleosome-binding domain-containing protein 3 is a protein that in humans is encoded by the HMGN3 gene. Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity)
Products for HMGN3 gene
Catalog | Product Name | Application | Company |
GFS:E02128 | high mobility group nucleosomal binding domain 3; ELISA kit | ELISA | n/a |
GFS:A02128 | high mobility group nucleosomal binding domain 3; Anti | ANTIBODIES | n/a |
GFS:P02128 | high mobility group nucleosomal binding domain 3; Protien | Protien | n/a |