Symbol: Name: ID: |
CHMP4B chromatin modifying protein 4B GFS:5297 |
Gene name: | CHMP4B |
Chromosome: | 20q11.22 |
Previous Symbols: | C20orf178 |
Previous Names: | chromosome 20 open reading frame 178 |
Aliases: | dJ553F4.4, Shax1, SNF7-2, VPS32B |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1922858 | Rat Genome Database ID: | |
HGNC ID: | HGNC:16171 | RefSeq IDs: | NM_176812 |
Entrez Gene ID: | 128866 | Ensembl Gene ID: | ENSG00000101421 |
VEGA IDs: | OTTHUMG00000032272 | UniProt ID: | Q9H444 |
UCSC ID: | uc002xaa.2 | OMIM ID: | 610897 |
Pubmed: | PMID14678797 | ||
CCDS IDs: | CCDSCCDS13228.1 |
Charged multivesicular body protein 4b is a protein that in humans is encoded by the CHMP4B gene.
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for CHMP4B gene
Catalog | Product Name | Application | Company |
GFS:E05297 | chromatin modifying protein 4B; ELISA kit | ELISA | n/a |
GFS:A05297 | chromatin modifying protein 4B; Anti | ANTIBODIES | n/a |
GFS:P05297 | chromatin modifying protein 4B; Protien | Protien | n/a |