Symbol: Name: ID: |
CCL5 chemokine (C-C motif) ligand 5 GFS:557 |
Gene name: | CCL5 |
Chromosome: | 17q11.2-q12 |
Previous Symbols: | D17S136E, SCYA5 |
Previous Names: | small inducible cytokine A5 (RANTES) |
Aliases: | RANTES, SISd, TCP228, MGC17164 |
Name Aliases: | T-cell specific protein p288, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98262 | Rat Genome Database ID: | RGD:69069 |
HGNC ID: | HGNC:10632 | RefSeq IDs: | NM_002985 |
Entrez Gene ID: | 6352 | Ensembl Gene ID: | ENSG00000161570 |
VEGA IDs: | OTTHUMG00000132949 | UniProt ID: | P13501 |
UCSC ID: | uc002hkf.2 | OMIM ID: | 187011 |
Pubmed: | PMID1691736 | ||
CCDS IDs: | CCDSCCDS11300.1 |
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils
Products for CCL5 gene
Catalog | Product Name | Application | Company |
GFS:E00557 | chemokine (C-C motif) ligand 5; ELISA kit | ELISA | n/a |
GFS:A00557 | chemokine (C-C motif) ligand 5; Anti | ANTIBODIES | n/a |
GFS:P00557 | chemokine (C-C motif) ligand 5; Protien | Protien | n/a |