Symbol: Name: ID: |
CCL20 chemokine (C-C motif) ligand 20 GFS:542 |
Gene name: | CCL20 |
Chromosome: | 2q33-q37 |
Previous Symbols: | SCYA20 |
Previous Names: | small inducible cytokine subfamily A (Cys-Cys), member 20 |
Aliases: | LARC, MIP-3a, exodus-1, ST38, CKb4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1329031 | Rat Genome Database ID: | RGD:3646 |
HGNC ID: | HGNC:10619 | RefSeq IDs: | NM_001130046 |
Entrez Gene ID: | 6364 | Ensembl Gene ID: | ENSG00000115009 |
VEGA IDs: | OTTHUMG00000133189 | UniProt ID: | P78556 |
UCSC ID: | uc002vpl.2 | OMIM ID: | 601960 |
Pubmed: | PMID9038201 PMID 11352563 | ||
CCDS IDs: | CCDSCCDS2469.1 CCDS CCDS46536.1 |
Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues. CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.
Gene expression of CCL20 can be induced by microbial factors such as lipopolysaccharide (LPS), and inflammatory cytokines such as tumor necrosis factor and interferon-γ, and down-regulated by IL-10.CCL20 is expressed in several tissues with highest expression observed in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung and lower levels in thymus, testis, prostate and gut.The gene for CCL20 (scya20) is located on chromosome 2 in humans.
Products for CCL20 gene
Catalog | Product Name | Application | Company |
GFS:E00542 | chemokine (C-C motif) ligand 20; ELISA kit | ELISA | n/a |
GFS:A00542 | chemokine (C-C motif) ligand 20; Anti | ANTIBODIES | n/a |
GFS:P00542 | chemokine (C-C motif) ligand 20; Protien | Protien | n/a |