Symbol: Name: ID: |
CCL2 chemokine (C-C motif) ligand 2 GFS:541 |
Gene name: | CCL2 |
Chromosome: | 17q11.2-q21.1 |
Previous Symbols: | SCYA2 |
Previous Names: | small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je) |
Aliases: | MCP1, MCP-1, MCAF, SMC-CF, GDCF-2, HC11, MGC9434 |
Name Aliases: | monocyte chemotactic protein 1, homologous to mouse Sig-je, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98259 | Rat Genome Database ID: | RGD:3645 |
HGNC ID: | HGNC:10618 | RefSeq IDs: | NM_002982 |
Entrez Gene ID: | 6347 | Ensembl Gene ID: | ENSG00000108691 |
VEGA IDs: | OTTHUMG00000132887 | UniProt ID: | P13500 |
UCSC ID: | uc002hhy.2 | OMIM ID: | 158105 |
Pubmed: | PMID2004761 | ||
CCDS IDs: | CCDSCCDS11277.1 |
CCL2 is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis
Products for CCL2 gene
Catalog | Product Name | Application | Company |
GFS:E00541 | chemokine (C-C motif) ligand 2; ELISA kit | ELISA | n/a |
GFS:A00541 | chemokine (C-C motif) ligand 2; Anti | ANTIBODIES | n/a |
GFS:P00541 | chemokine (C-C motif) ligand 2; Protien | Protien | n/a |