Symbol: Name: ID: |
CDC73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) GFS:5868 |
Gene name: | CDC73 |
Chromosome: | 1q25 |
Previous Symbols: | C1orf28, HRPT2 |
Previous Names: | chromosome 1 open reading frame 28, "hyperparathyroidism 2 (with jaw tumor)" |
Aliases: | parafibromin |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2384876 | Rat Genome Database ID: | RGD:1311766 |
HGNC ID: | HGNC:16783 | RefSeq IDs: | NM_024529 |
Entrez Gene ID: | 79577 | Ensembl Gene ID: | ENSG00000134371 |
VEGA IDs: | OTTHUMG00000035676 | UniProt ID: | Q6P1J9 |
UCSC ID: | uc001gtb.2 | OMIM ID: | 607393 |
Pubmed: | PMID11318611 PMID 15632063 | ||
CCDS IDs: | CCDSCCDS1382.1 |
Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae), also known as CDC73 and parafibromin, is a protein which in humans is encoded by the CDC73 gene.
This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.
Products for CDC73 gene
Catalog | Product Name | Application | Company |
GFS:E05868 | cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A05868 | cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P05868 | cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); Protien | Protien | n/a |