Symbol: Name: ID: |
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) GFS:6277 |
Gene name: | CDC14B |
Chromosome: | 9q22.3 |
Previous Symbols: | |
Previous Names: | CDC14 (cell division cycle 14, S. cerevisiae) homolog B |
Aliases: | Cdc14B1, Cdc14B2, CDC14B3, hCDC14B |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2441808 | Rat Genome Database ID: | RGD:1311163 |
HGNC ID: | HGNC:1719 | RefSeq IDs: | NM_001077181 |
Entrez Gene ID: | 8555 | Ensembl Gene ID: | ENSG00000081377 |
VEGA IDs: | OTTHUMG00000020300 | UniProt ID: | O60729 |
UCSC ID: | uc004awj.2 | OMIM ID: | 603505 |
Pubmed: | PMID9367992 | ||
CCDS IDs: | CCDSCCDS6721.1 CCDS CCDS6722.1 CCDS CCDS43853.1 |
Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene.
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Function: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
Products for CDC14B gene
Catalog | Product Name | Application | Company |
GFS:E06277 | CDC14 cell division cycle 14 homolog B (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A06277 | CDC14 cell division cycle 14 homolog B (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P06277 | CDC14 cell division cycle 14 homolog B (S. cerevisiae); Protien | Protien | n/a |