Symbol: Name: ID: |
CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae) GFS:6267 |
Gene name: | CDC14A |
Chromosome: | 1p21 |
Previous Symbols: | |
Previous Names: | CDC10 (cell division cycle 10, S. cerevisiae, homolog) |
Aliases: | Cdc14A1, Cdc14A2, cdc14 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2442676 | Rat Genome Database ID: | RGD:1304649 |
HGNC ID: | HGNC:1718 | RefSeq IDs: | NM_003672 |
Entrez Gene ID: | 8556 | Ensembl Gene ID: | ENSG00000079335 |
VEGA IDs: | OTTHUMG00000010987 | UniProt ID: | Q9UNH5 |
UCSC ID: | uc001dtf.2 | OMIM ID: | 603504 |
Pubmed: | PMID9367992 PMID 10409437 | ||
CCDS IDs: | CCDSCCDS769.1 CCDS CCDS770.1 CCDS CCDS771.1 |
Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Function: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.
Products for CDC14A gene
Catalog | Product Name | Application | Company |
GFS:E06267 | CDC14 cell division cycle 14 homolog A (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A06267 | CDC14 cell division cycle 14 homolog A (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P06267 | CDC14 cell division cycle 14 homolog A (S. cerevisiae); Protien | Protien | n/a |