| Symbol: Name: ID: |
CDC45 cell division cycle 45 homolog (S. cerevisiae) GFS:6464 |
| Gene name: | CDC45 |
| Chromosome: | 22q11.21 |
| Previous Symbols: | CDC45L2, CDC45L |
| Previous Names: | CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like, "CDC45 cell division cycle 45-like (S. cerevisiae)" |
| Aliases: | |
| Name Aliases: | human CDC45 |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1338073 | Rat Genome Database ID: | RGD:1590928 |
| HGNC ID: | HGNC:1739 | RefSeq IDs: | NM_001178010 |
| Entrez Gene ID: | 8318 | Ensembl Gene ID: | ENSG00000093009 |
| VEGA IDs: | OTTHUMG00000150386 | UniProt ID: | O75419 |
| UCSC ID: | uc002zpr.2 | OMIM ID: | 603465 |
| Pubmed: | PMID9660782 PMID 9724329 PMID 17608804 | ||
| CCDS IDs: | CCDSCCDS13762.1 | ||
CDC45 is a protein that in humans is encoded by the CDC45L gene.
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010].
Function: Required for initiation of chromosomal DNA replication.
Products for CDC45 gene
| Catalog | Product Name | Application | Company |
| GFS:E06464 | cell division cycle 45 homolog (S. cerevisiae); ELISA kit | ELISA | n/a |
| GFS:A06464 | cell division cycle 45 homolog (S. cerevisiae); Anti | ANTIBODIES | n/a |
| GFS:P06464 | cell division cycle 45 homolog (S. cerevisiae); Protien | Protien | n/a |
