Symbol: Name: ID: |
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) GFS:6438 |
Gene name: | CDC42 |
Chromosome: | 1p36.1 |
Previous Symbols: | |
Previous Names: | cell division cycle 42 (GTP-binding protein, 25kD) |
Aliases: | G25K, CDC42Hs |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:106211 | Rat Genome Database ID: | RGD:71043 |
HGNC ID: | HGNC:1736 | RefSeq IDs: | NM_001039802 |
Entrez Gene ID: | 998 | Ensembl Gene ID: | ENSG00000070831 |
VEGA IDs: | OTTHUMG00000002753 | UniProt ID: | P60953 |
UCSC ID: | uc001bfr.2 | OMIM ID: | 116952 |
Pubmed: | PMID2124704 PMID 2122236 | ||
CCDS IDs: | CCDSCCDS221.1 CCDS CCDS222.1 |
Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene.
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Causes the formation of thin, actin-rich surface projections called filopodia.
Products for CDC42 gene
Catalog | Product Name | Application | Company |
GFS:E06438 | cell division cycle 42 (GTP binding protein, 25kDa); ELISA kit | ELISA | n/a |
GFS:A06438 | cell division cycle 42 (GTP binding protein, 25kDa); Anti | ANTIBODIES | n/a |
GFS:P06438 | cell division cycle 42 (GTP binding protein, 25kDa); Protien | Protien | n/a |