Symbol: Name: ID: |
CDC34 cell division cycle 34 homolog (S. cerevisiae) GFS:6417 |
Gene name: | CDC34 |
Chromosome: | 19p13.3 |
Previous Symbols: | |
Previous Names: | cell division cycle 34 |
Aliases: | E2-CDC34, UBE2R1, UBC3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:102657 | Rat Genome Database ID: | RGD:1305411 |
HGNC ID: | HGNC:1734 | RefSeq IDs: | NM_004359 |
Entrez Gene ID: | 997 | Ensembl Gene ID: | ENSG00000099804 |
VEGA IDs: | UniProt ID: | P49427 | |
UCSC ID: | uc002lov.2 | OMIM ID: | 116948 |
Pubmed: | PMID8248134 PMID 16210246 | ||
CCDS IDs: | CCDSCCDS12030.1 |
Ubiquitin-conjugating enzyme E2 R1 is a protein that in humans is encoded by the CDC34 gene.
The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase throught its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes.
Products for CDC34 gene
Catalog | Product Name | Application | Company |
GFS:E06417 | cell division cycle 34 homolog (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A06417 | cell division cycle 34 homolog (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P06417 | cell division cycle 34 homolog (S. cerevisiae); Protien | Protien | n/a |