Symbol: Name: ID: |
CDC25A cell division cycle 25 homolog A (S. pombe) GFS:6330 |
Gene name: | CDC25A |
Chromosome: | 3p21 |
Previous Symbols: | |
Previous Names: | cell division cycle 25A, "cell division cycle 25 homolog A (S. cerevisiae)" |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103198 | Rat Genome Database ID: | RGD:621498 |
HGNC ID: | HGNC:1725 | RefSeq IDs: | NM_001789 |
Entrez Gene ID: | 993 | Ensembl Gene ID: | ENSG00000164045 |
VEGA IDs: | OTTHUMG00000133535 | UniProt ID: | P30304 |
UCSC ID: | uc003csh.1 | OMIM ID: | 116947 |
Pubmed: | PMID1836978 | ||
CCDS IDs: | CCDSCCDS2760.1 CCDS CCDS2761.1 |
Cell division cycle 25 homolog A (S. pombe), also known as CDC25A, is a mammalian gene.
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
Products for CDC25A gene
Catalog | Product Name | Application | Company |
GFS:E06330 | cell division cycle 25 homolog A (S. pombe); ELISA kit | ELISA | n/a |
GFS:A06330 | cell division cycle 25 homolog A (S. pombe); Anti | ANTIBODIES | n/a |
GFS:P06330 | cell division cycle 25 homolog A (S. pombe); Protien | Protien | n/a |