Symbol: Name: ID: |
CDC23 cell division cycle 23 homolog (S. cerevisiae) GFS:6325 |
Gene name: | CDC23 |
Chromosome: | 5q31 |
Previous Symbols: | |
Previous Names: | CDC23 (cell division cycle 23, yeast, homolog), "CDC23 (cell division cycle 23, yeast, homolog)" |
Aliases: | APC8, ANAPC8, CUT23 |
Name Aliases: | anaphase promoting complex subunit 8 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1098815 | Rat Genome Database ID: | |
HGNC ID: | HGNC:1724 | RefSeq IDs: | NM_004661 |
Entrez Gene ID: | 8697 | Ensembl Gene ID: | ENSG00000094880 |
VEGA IDs: | OTTHUMG00000129198 | UniProt ID: | Q9UJX2 |
UCSC ID: | uc003lcl.2 | OMIM ID: | 603462 |
Pubmed: | PMID9790767 | ||
CCDS IDs: | CCDSCCDS4200.2 |
Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that in humans is encoded by the CDC23 gene.
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Products for CDC23 gene
Catalog | Product Name | Application | Company |
GFS:E06325 | cell division cycle 23 homolog (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A06325 | cell division cycle 23 homolog (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P06325 | cell division cycle 23 homolog (S. cerevisiae); Protien | Protien | n/a |