Symbol: Name: ID: |
CARD8 caspase recruitment domain family, member 8 GFS:6150 |
Gene name: | CARD8 |
Chromosome: | 19q13.33 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TUCAN, KIAA0955, CARDINAL, NDPP, Dakar |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:17057 | RefSeq IDs: | NM_001184900 |
Entrez Gene ID: | 22900 | Ensembl Gene ID: | ENSG00000105483 |
VEGA IDs: | OTTHUMG00000071812 | UniProt ID: | Q9Y2G2 |
UCSC ID: | uc002pie.3 | OMIM ID: | 609051 |
Pubmed: | PMID10231032 PMID 11408476 | ||
CCDS IDs: | CCDSCCDS12712.1 |
Caspase recruitment domain-containing protein 8 is an enzyme that in humans is encoded by the CARD8 gene.
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010].
Function: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.
Products for CARD8 gene
Catalog | Product Name | Application | Company |
GFS:E06150 | caspase recruitment domain family, member 8; ELISA kit | ELISA | n/a |
GFS:A06150 | caspase recruitment domain family, member 8; Anti | ANTIBODIES | n/a |
GFS:P06150 | caspase recruitment domain family, member 8; Protien | Protien | n/a |