Symbol: Name: ID: |
CARD11 caspase recruitment domain family, member 11 GFS:5509 |
Gene name: | CARD11 |
Chromosome: | 7p22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CARMA1, BIMP3 |
Name Aliases: | card-maguk protein 1, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1916978 | Rat Genome Database ID: | |
HGNC ID: | HGNC:16393 | RefSeq IDs: | NM_032415 |
Entrez Gene ID: | 84433 | Ensembl Gene ID: | ENSG00000198286 |
VEGA IDs: | OTTHUMG00000023023 | UniProt ID: | Q9BXL7 |
UCSC ID: | uc003smv.2 | OMIM ID: | 607210 |
Pubmed: | PMID11278692 PMID 11356195 | ||
CCDS IDs: | CCDSCCDS5336.2 |
Caspase recruitment domain-containing protein 11 also known as CARD-containing MAGUK protein 1 (Carma 1) is a protein that in humans is encoded by the CARD11 gene.
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
Products for CARD11 gene
Catalog | Product Name | Application | Company |
GFS:E05509 | caspase recruitment domain family, member 11; ELISA kit | ELISA | n/a |
GFS:A05509 | caspase recruitment domain family, member 11; Anti | ANTIBODIES | n/a |
GFS:P05509 | caspase recruitment domain family, member 11; Protien | Protien | n/a |