Symbol: Name: ID: |
PYCARD PYD and CARD domain containing GFS:5712 |
Gene name: | PYCARD |
Chromosome: | 16p11.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TMS-1, CARD5, ASC |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1931465 | Rat Genome Database ID: | RGD:628637 |
HGNC ID: | HGNC:16608 | RefSeq IDs: | NM_013258 |
Entrez Gene ID: | 29108 | Ensembl Gene ID: | ENSG00000103490 |
VEGA IDs: | OTTHUMG00000132405 | UniProt ID: | Q9ULZ3 |
UCSC ID: | uc010cak.2 | OMIM ID: | 606838 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS10708.1 CCDS CCDS10709.1 |
Apoptosis-associated speck-like protein containing a CARD or ASC is a protein that in humans is encoded by the PYCARD gene.
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
Products for PYCARD gene
Catalog | Product Name | Application | Company |
GFS:E05712 | PYD and CARD domain containing; ELISA kit | ELISA | n/a |
GFS:A05712 | PYD and CARD domain containing; Anti | ANTIBODIES | n/a |
GFS:P05712 | PYD and CARD domain containing; Protien | Protien | n/a |