Symbol: Name: ID: |
CARD14 caspase recruitment domain family, member 14 GFS:5554 |
Gene name: | CARD14 |
Chromosome: | 17q25 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CARMA2, BIMP2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2386258 | Rat Genome Database ID: | |
HGNC ID: | HGNC:16446 | RefSeq IDs: | NM_024110 |
Entrez Gene ID: | 79092 | Ensembl Gene ID: | ENSG00000141527 |
VEGA IDs: | UniProt ID: | Q9BXL6 | |
UCSC ID: | uc002jxw.1 | OMIM ID: | 607211 |
Pubmed: | PMID11278692 PMID 11356195 | ||
CCDS IDs: | CCDSCCDS11768.1 CCDS CCDS11769.1 |
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Function: Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
Products for CARD14 gene
Catalog | Product Name | Application | Company |
GFS:E05554 | caspase recruitment domain family, member 14; ELISA kit | ELISA | n/a |
GFS:A05554 | caspase recruitment domain family, member 14; Anti | ANTIBODIES | n/a |
GFS:P05554 | caspase recruitment domain family, member 14; Protien | Protien | n/a |