Symbol: Name: ID: |
TBX5 T-box 5 GFS:1455 |
Gene name: | TBX5 |
Chromosome: | 12q24.1 |
Previous Symbols: | HOS |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:102541 | Rat Genome Database ID: | RGD:1305702 |
HGNC ID: | HGNC:11604 | RefSeq IDs: | NM_000192 |
Entrez Gene ID: | 6910 | Ensembl Gene ID: | ENSG00000089225 |
VEGA IDs: | UniProt ID: | Q99593 | |
UCSC ID: | uc001tvo.2 | OMIM ID: | 601620 |
Pubmed: | PMID8988165 PMID 8054982 | ||
CCDS IDs: | CCDSCCDS9173.1 CCDS CCDS9174.1 CCDS CCDS41840.1 |
T-box transcription factor TBX5 is a protein that in humans is encoded by the TBX5 gene. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq].
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation.
Products for TBX5 gene
Catalog | Product Name | Application | Company |
GFS:E01455 | T-box 5; ELISA kit | ELISA | n/a |
GFS:A01455 | T-box 5; Anti | ANTIBODIES | n/a |
GFS:P01455 | T-box 5; Protien | Protien | n/a |