Symbol: Name: ID: |
TBX21 T-box 21 GFS:1449 |
Gene name: | TBX21 |
Chromosome: | 17q21.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TBLYM, T-bet |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1888984 | Rat Genome Database ID: | RGD:1308264 |
HGNC ID: | HGNC:11599 | RefSeq IDs: | NM_013351 |
Entrez Gene ID: | 30009 | Ensembl Gene ID: | ENSG00000073861 |
VEGA IDs: | UniProt ID: | Q9UL17 | |
UCSC ID: | uc002ilv.1 | OMIM ID: | 604895 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS11514.1 |
T-box transcription factor TBX21 is a protein that in humans is encoded by the TBX21 gene. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.
Products for TBX21 gene
Catalog | Product Name | Application | Company |
GFS:E01449 | T-box 21; ELISA kit | ELISA | n/a |
GFS:A01449 | T-box 21; Anti | ANTIBODIES | n/a |
GFS:P01449 | T-box 21; Protien | Protien | n/a |