Symbol: Name: ID: |
TBXA2R thromboxane A2 receptor GFS:1458 |
Gene name: | TBXA2R |
Chromosome: | 19p13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98496 | Rat Genome Database ID: | RGD:3825 |
HGNC ID: | HGNC:11608 | RefSeq IDs: | NM_001060 |
Entrez Gene ID: | 6915 | Ensembl Gene ID: | ENSG00000006638 |
VEGA IDs: | UniProt ID: | P21731 | |
UCSC ID: | uc002lyg.1 | OMIM ID: | 188070 |
Pubmed: | PMID1825698 | ||
CCDS IDs: | CCDSCCDS42467.1 |
The thromboxane receptor (TP) is a protein on the surface of cells in the endothelium of blood vessels and in the placenta which interacts with the eicosanoid lipid thromboxane. It is a G-protein coupled receptor coupled to the G protein Gq. This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
Products for TBXA2R gene
Catalog | Product Name | Application | Company |
GFS:E01458 | thromboxane A2 receptor; ELISA kit | ELISA | n/a |
GFS:A01458 | thromboxane A2 receptor; Anti | ANTIBODIES | n/a |
GFS:P01458 | thromboxane A2 receptor; Protien | Protien | n/a |