Symbol: Name: ID: |
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) GFS:3051 |
Gene name: | VPS35 |
Chromosome: | 16q12 |
Previous Symbols: | |
Previous Names: | vacuolar protein sorting 35 (yeast homolog), "vacuolar protein sorting 35 (yeast)" |
Aliases: | FLJ10752, MEM3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1890467 | Rat Genome Database ID: | RGD:1589784 |
HGNC ID: | HGNC:13487 | RefSeq IDs: | NM_018206 |
Entrez Gene ID: | 55737 | Ensembl Gene ID: | ENSG00000069329 |
VEGA IDs: | OTTHUMG00000132542 | UniProt ID: | Q96QK1 |
UCSC ID: | uc002eef.3 | OMIM ID: | 601501 |
Pubmed: | PMID11112353 | ||
CCDS IDs: | CCDSCCDS10721.1 |
Vacuolar protein sorting-associated protein 35 is a protein that in humans is encoded by the VPS35 gene.
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA).
Products for VPS35 gene
Catalog | Product Name | Application | Company |
GFS:E03051 | vacuolar protein sorting 35 homolog (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A03051 | vacuolar protein sorting 35 homolog (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P03051 | vacuolar protein sorting 35 homolog (S. cerevisiae); Protien | Protien | n/a |